Photoaging Treatment with Retinoid

Skin aging is a very intersting biological process. There are two types of aging: intrinsic or biological one and photoagin. While intrinsic or chronological aging is an inevitable process, photoaging involves the premature aging of skin occurring due to cumulative exposure to ultraviolet radiation. Chronological and photoaging both have clinically differentiable manifestations.


Treating Photo-Aging with Retinol

The skin, being the ultimate protective barrier between the internal organs and the environment, is exposed to ultraviolet (UV) irradiation and to a lesser extent to other DNA damaging agents such as cigarette smoke, automobile exhaust, and professional exposure. Yet solar UV radiation unquestionably is the single major factor responsible for skin aging. Photoaging is pretty much a collection of photodamage on intrinsically aged skin. Usually, it is the main factor that brings premature aging in most people. This skin damage occurs by chronic exposure of the skin to UV light. Typically, the skin becomes coarse. Epidermis thickens (hyperplasia) at first. Then it thins out, and a face starts showing laxity, sallowness with wrinkles, irregular hyperpigmentation, lentigines (sun spots). Prolong exposure to sun also affects micro-cirtulation. Small blood vessels in a face become constantly dilated and twisted, creating telangiectasia.




Telangiectasia Treatment




So how can you treat photoaging? And can you treat it at all? Well, various natural and synthetic retinoids have been explored for the treatment of photoaging and many of them have shown histological and clinical improvement. Retinol and retinoids were introduced into the treatment of various skin problems, including acne and photoaging more than twenty years ago. The importance of retinol, a vitamin A derivative, was first discovered during World War I. Subsequent research was launched in 1968 to synthesize compounds similar to vitamin A by chemical manipulation of its molecule to improve clinical efficacy and safety.




Retinol with Glycolic Acid Cream





Today, the retinoid family comprises retinol and its natural derivatives such as retinaldehyde, retinoic acid, and retinyl esters. There is also a fairly large large number of synthetic retinol derivatives such as Tazarotene, Adapalene, and Alitretinoin. Both types of retinoids woks by influencing cellular growth and differentiation, cell surface alterations, and immune modulation. Sounds pretty complicated))) However, the end result is that they reduce inflammation, hyper-pigmentation, small wrinkles.






Adapalene Retinol Gel





Retinol and other retinoids are usually applied once a day, usually at bedtime. They come in cream and gel formulations. Some are even combined with antibiotics, vitamin C, or glycolic acid. They results are often seen after about 12 to 24 weeks. Yes, they are not magic))) You really need to use them a long time to see real results. People with sever photo-aging should probably apply these products for close to a year in order to reverse all the skin damage. Which retinoid should you use for anti-aging? Well, they all work pretty much the same. However, the new synthetic retinoids have a lot less side-effects. But, they are a lot more expensive and if you live in UK, they do require prescription.

The most common and frequent side effect of all retinoids are known as ‘retinol reaction’. It is redness, itching, mild peeling, and slight burning sensation at site of application. It is more common with tretinoin and tazarotene than with isotretinoin, adapalene, retinol, and retinaldehyde. The "retinol reaction" usually happens within the first few days of treatment. It is not serious and it goes away with continued use. To counteract these symptoms, reduction in the frequency of application or switching to a less irritating retinoid is normally advised. The other side effect associated with retinol therapy is photosensitization. Your skin becomes more sensitive to sunlight. Therefore, people who use any kind of retinol are advised to avoid excessive sun exposure and take precautionary measures (like use of sunscreens) for sun protection. But you should be doing it anyway, if you are worried about aging)))

So, to conclude, retinol and other retinoids are the most promising agents that are available for the treatment of aging. Amongst retinoids, tretinoin is the most potent and best-studied retinoid. However, its irritation potential has prompted dermatologists to switch over to less irritating but comparably effective retinoids like adapalene and to some extent retinol and retinaldehyde. In addition, retinoid therapy can be combined with laser treatments, chemical peels, and other procedures in order to reverse signs of aging.









Chemical Peels and Skincare Supplies for UK